Name :
KLF1 Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to KLF1
Tested applications :
WB
Species reactivity :
Human, Mouse, Rat
Alternative names :
KLF1 antibody; EKLF antibody; CDAN4 antibody; HBFQTL6 antibody; INLU antibody; Kruppel like factor 1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KLF1 (NP_006554.1).
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.
Applications :
WB 1:500 – 1:2000
Background :
Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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