Name :
KLHL3 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
KLHL3 Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, HL-60 cells, human liver tissue, Jurkat cells, mouse liver tissue, mouse thymus tissue, rat liver tissue. Positive IP detected in HepG2 cells. Positive IHC detected in human liver tissue, human tonsillitis tissue. Observed molecular weight by Western-blot: 65 kDa
Tested applications :
ELISA, WB, IHC, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
FLJ40871 antibody; kelch like 3 (Drosophila) antibody; Kelch like protein 3 antibody; KIAA1129 antibody; KLHL3 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of KLHL3 recombinant protein (Accession Number: BC034035). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200
Background :
KLHL3 represents kelch-like 3 (Drosophila)
References :
Louis-Dit-Picard H, Barc J, Trujillano D. KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron. Nature genetics. 44(4):456-60, S1-3. 2012. Susa K, Sohara E, Rai T. Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice. Human molecular genetics. 23(19):5052-60. 2014. Zeniya M, Morimoto N, Takahashi D. Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus. Journal of the American Society of Nephrology : JASN. 26(9):2129-38. 2015. Mori Y, Mori T, Wakabayashi M. Involvement of selective autophagy mediated by p62/SQSTM1 in KLHL3-dependent WNK4 degradation. The Biochemical journal. 472(1):33-41. 2015. Yoshizaki Y, Mori Y, Tsuzaki Y. Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3. Biochemical and biophysical research communications. 467(2):229-34. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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