Name :
L3MBTL1 Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to L3MBTL1
Tested applications :
IF
Species reactivity :
Human
Alternative names :
L3MBTL1 antibody; H-LMBT antibody; L3MBTL antibody; ZC2HC3 antibody; dJ138B7.3 antibody; lmbt-like 1 (Drosophila) antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 533-772 of human L3MBTL1 (NP_056293.4).
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.
Applications :
IF 1:50 – 1:100
Background :
Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a ‘reader’ of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at ‘Lys-26’ (H1bK26me1 and H1bK26me2) and histone H4 at ‘Lys-20’ (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at ‘Lys-382’, leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at ‘Lys-860’. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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