Name :
LAPTM4B antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
LAPTM4B Rabbit Polyclonal antibody. Positive IHC detected in human liver cancer tissue, human heart tissue. Positive WB detected in mouse lymph tissue, rat lymph tissue. Observed molecular weight by Western-blot: 24 kDa
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
LAPTM4B antibody; LAPTM4beta antibody; LC27 antibody
Immunogen :
Human LAPTM4B Recombinant protein (His tag)
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of LAPTM4B recombinant protein (Accession Number: NM_018407). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200
Background :
LAPTM4B, a novel oncoprotein, is associated with the prognosis of cancer, and may play important roles in the initiation, promotion and metastasis of tumors. It was initially identified as a hepatocellular carcinoma-associated gene, and was recently shown to be up-regulated in various human cancers. Some studies indicated that LAPTM4B may be an useful marker of prognosis in ovarian carcinoma and endometrial cancer. LAPTM4B belongs to the LAPTM4/LAPTM5 transporter family. It has 3 isoforms with molecular masses 41kd, 35 kd and 24 kd. This antibody can recognize all the 3 isoforms of LAPTM4B.
References :
Tan X, Thapa N, Sun Y, Anderson RA. A kinase-independent role for EGF receptor in autophagy initiation. Cell. 160(1-2):145-60. 2015. Milkereit R, Persaud A, Vanoaica L, Guetg A, Verrey F, Rotin D. LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation. Nature communications. 6:7250. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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