Name :
LATS2-Specific antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
LATS2-Specific Rabbit Polyclonal antibody. Positive WB detected in SGC-7901 cells, human brain tissue, human heart tissue, mouse brain tissue. Positive IHC detected in human heart tissue, human colon tissue. Positive IF detected in HepG2 cells. Positive FC detected in HeLa cells. Observed molecular weight by Western-blot: 150kd
Tested applications :
ELISA, WB, IHC, FC, IF
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
FLJ13161 antibody; KPM antibody; LATS2 antibody; Warts like kinase antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Peptide (Accession Number: NM_014572). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200IF: 1:20-1:200
Background :
LATS2, also named as KPM, belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. LATS2 is a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. It negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. It is a negative regulator of the androgen receptor. The antibody is specific to LATS2.
References :
Sun D, Yu F, Ma Y. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1). The Journal of biological chemistry. 288(13):9508-18. 2013.
Related websites: https://www.medchemexpress.com/antibodies.html
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