Name :
LCOR antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
LCOR Rabbit Polyclonal antibody. Positive IF detected in HeLa cells. Positive IHC detected in human endometrial cancer tissue. Positive WB detected in HeLa cells. Observed molecular weight by Western-blot: 50 kDa
Tested applications :
ELISA, WB, IHC, IF
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
FLJ38026 antibody; KIAA1795 antibody; LCOR antibody; Ligand dependent corepressor antibody; Mblk1 related protein 2 antibody; MLR2 antibody; RP11 175O19.1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of LCOR recombinant protein (Accession Number: NM_001170766). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:1000IHC: 1:20-1:200IF: 1:50-1:500
Background :
LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box [PMID:12535528]. It functions through recruitment of C-terminal binding proteins (CtBPs) and histone deacetylases (HDACs) to its N-terminal and central domains, respectively [PMID:22277651]. It is a scaffold for both histone deacetylases (HDACs) and C-terminal binding protein (CtBP) corepressors and functions by both HDAC-dependent and -independent mechanisms in a receptor-specific manner[PMID:19744932].
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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