Name :
LEPR antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
LEPR Rabbit Polyclonal antibody. Positive FC detected in HeLa cells. Positive IF detected in MCF-7 cells. Positive IHC detected in human prostate hyperplasia tissue, human heart tissue. Positive IP detected in mouse heart tissue. Positive WB detected in mouse heart tissue, PC-3 cells. Observed molecular weight by Western-blot: 150 kDa
Tested applications :
ELISA, IHC, IF, WB, IP, FC
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
CD295 antibody; HuB219 antibody; LEP R antibody; LEPR antibody; leptin receptor antibody; OB R antibody; OB receptor antibody; OBR antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Peptide (Accession Number: NM_002303). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:10-1:100
Background :
The hormone leptin, secreted predominantly from adipose tissue, plays a crucial role in the regulation of numerous neuroendocrine functions, from energy homeostasis to reproduction (PMID: 22249808). Leptin acts through the leptin receptor (LEPR, also known as OB-R), a single-transmembrane-domain receptor of the cytokine receptor family. On ligand binding, LEPR mediates signaling through JAK2/STAT3 (PMID: 9102398). LEPR plays an important role in the regulation of glucose homeostasis via feeding and adiposity. Alternatively spliced transcript variants encoding different isoforms of LEPR have been described. This antibody can recognize long (LEPRb) and short (LEPRa,c,d) isoforms.
References :
Fan Y, Gan Y, Shen Y. Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production. Oncotarget. 6(18):16120-34. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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