Name :
LGP2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
LGP2 Rabbit Polyclonal antibody. Positive IP detected in mouse liver tissue. Positive WB detected in HEK-293 cells. Positive IHC detected in human breast cancer tissue. Observed molecular weight by Western-blot: 77 kDa
Tested applications :
ELISA, IHC, IP, WB
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
D11LGP2 antibody; D11lgp2e antibody; DHX58 antibody; LGP2 antibody; Protein D11Lgp2 homolog antibody; RIG I like receptor LGP2 antibody; RLR antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of LGP2 recombinant protein (Accession Number: XM_047436724). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:1000IP: 1:200-1:1000IHC: 1:10-1:100
Background :
DHX58(Probable ATP-dependent RNA helicase DHX58) is also named as D11LGP2E, LGP2 and belongs to the RLR subfamily. DHX58, originally identified as a highly expressed gene in mammary tumors, is another cytoplasmic DEX(D/H)-box helicase that can recognize RNA(PMID: 18411269). It acts as a positive, but not negative, regulator of RIG-I– and MDA5-dependent recognition of RNA virus infection and plays a pivotal role in antiviral responses in vivo(PMID:20080593).
References :
Furr SR, Chauhan VS, Sterka D, Grdzelishvili V, Marriott I. Characterization of retinoic acid-inducible gene-I expression in primary murine glia following exposure to vesicular stomatitis virus. Journal of neurovirology. 14(6):503-13. 2008. Chopy D, Pothlichet J, Lafage M. Ambivalent role of the innate immune response in rabies virus pathogenesis. Journal of virology. 85(13):6657-68. 2011.
Related websites: https://www.medchemexpress.com/antibodies.html
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