Name :
Anti-C4.4A/LYPD3 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Rabbit monoclonal to C4.4A/LYPD3
Tested applications :
ELISA, WB, FCM, IF, ICC/IF
Species reactivity :
Human C4.4A / LYPD3
Alternative names :
C4.4A antibody; C4.4a antibody; 2310061G07Rik antibody; C4.4a antibody; LYPD3 antibody; UNQ491/PRO1007 antibody; 2310061G07Rik antibody; C4.4A antibody; Lypd3 antibody
Immunogen :
Human C4.4A/LYPD3 (His Tag) recombinant protein
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained from a rabbit immunized with purified, recombinant Human C4.4A / LYPD3 (rh C4.4A / LYPD3; NP_055215.2; Met 1-His 286).
Clonality :
Monoclonal
Formulation :
0.2 μm filtered solution in PBS with 5% trehalose
Storage instructions :
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Applications :
WB: 5-10 μg/mLELISA: 0.1-0.2 μg/mLThis antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human LYPD3. The detection limit for Human LYPD3 is approximately 0.0049 ng/well.FCM: 0.5-2 μg/TestICC/IF: 10-25 μg/mL
Background :
Ly6 / PLAUR domain-containing protein 3, also known as GPI-anchored metastasis-associated protein C4.4A homolog, Matrigel-induced gene C4 protein, MIG-C4 and LYPD3, is a cell membrane protein which contains two UPAR/Ly6 domains. Human LYPD3 contains two UPAR/Ly6 domains. LYPD3 is expressed in placenta, skin and urothelium. It is found in suprabasal keratinocytes of chronic wounds. Weak expression of LYPD3 is found in esophagus and peripheral blood mononuclear cells. It is found in the majority of primary and metastatic transitional cell carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normal tissues. High expression of LYPD3 is found in the tumor component of some noninvasive superficial lesions and in invasive and metastatic urothelial cancers. LYPD3 is up-regulated in migrating keratinocytes during epithelisation of incisional skin wounds. LYPD3 supports cell migration. It may be involved in urothelial cell-matrix interactions. It may also be involved in tumor progression
References :
Smith B.A., et al., 2001, Cancer Res. 61:1678-85. Wuerfel J., et al., 2001, Gene 262:35-41. Clark H.F., et al., 2003, Genome Res. 13:2265-70. Fletcher G.C., et al., 2003, Br. J. Cancer 88:579-85. Hansen L.V., et al., 2004, Biochem. Eng. J. 380:845-57.
Related websites: https://www.medchemexpress.com/antibodies.html
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