Name :
Lin28A-specific antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Lin28A-specific Rabbit Polyclonal antibody. Positive WB detected in human heart tissue, hESC cells, human brain tissue, mouse liver tissue, NCCIT cell. Positive IHC detected in human small intestine tissue, human brain tissue, human heart tissue, human kidney tissue, human lung tissue, human ovary tissue, human spleen tissue, human testis tissue. Observed molecular weight by Western-blot: 28 kDa
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
CSDD1 antibody; FLJ12457 antibody; LIN 28 antibody; lin 28 homolog (C. elegans) antibody; Lin 28A antibody; LIN28 antibody; Lin28A antibody; Protein lin 28 homolog A antibody; ZCCHC1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Peptide (Accession Number: NM_024674). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200
Background :
LIN28 is one of the four key human factors (ocT4, SOX2, NANOG and LIN28) used to reprogram human fibroblasts to an embryonic stem (ES) cell-like state known as the induced pluripotent stem (Ips) cell. Lin28 is a marker of undifferentiated human embryonic stem cells and a cytoplasmic Mrna-binding protein that binds to and enhances the translation of the IGF2 Mrna. LIN28 has also been shown to bind to the let-7 pre-miRNA and block production of the mature let-7 microRNA in mouse embryonic stem cells. Affinity purified rabbit anti-LIN28 can be used to demonstrate pluripotency of ES and Ips cells, and to detect LIN28 transgene expression in the process of reprogramming. This antibody is a rabbit polyclonal antibody raised against a peptide mapping within human LIN28.This antibody recognize Lin28A specifically.
References :
Ali N, Allam H, May R. Hepatitis C virus-induced cancer stem cell-like signatures in cell culture and murine tumor xenografts. Journal of virology. 85(23):12292-303. 2011.
Related websites: https://www.medchemexpress.com/antibodies.html
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