Name :
Liprin alpha 1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Liprin alpha 1 Rabbit Polyclonal antibody. Positive FC detected in HeLa cells. Positive IHC detected in human prostate cancer tissue. Positive IF detected in HepG2 cells. Positive WB detected in HeLa cells, MCF7 cells. Positive IP detected in MCF-7 cells. Observed molecular weight by Western-blot: 160 kDa
Tested applications :
ELISA, WB, IHC, IF, IP, FC
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
FLJ41337 antibody; FLJ42630 antibody; FLJ43474 antibody; LAR interacting protein 1 antibody; LIP 1 antibody; LIP.1 antibody; LIP1 antibody; LIPRIN antibody; Liprin alpha 1 antibody; PPFIA1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Liprin alpha 1 recombinant protein (Accession Number: NM_003626). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:20-1:200
Background :
Liprin alpha 1, encoded by the PPFIA1 gene, is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. Liprin alpha 1 may regulate the disassembly of focal adhesions and thus help orchestrate cell-matrix interactions (PMID: 7796809). Alternatively spliced transcript variants encoding distinct isoforms have been described.
References :
Astro V, Chiaretti S, Magistrati E, Fivaz M, de Curtis I. Liprin-α1, ERC1 and LL5 define polarized and dynamic structures that are implicated in cell migration. Journal of cell science. 127(Pt 17):3862-76. 2014. Chiaretti S, Astro V, Chiricozzi E, de Curtis I. Effects of the scaffold proteins liprin-α1, β1 and β2 on invasion by breast cancer cells. Biology of the cell / under the auspices of the European Cell Biology Organization. 108(3):65-75. 2016. Choi EJ, Yun JA, Jabeen S. Prognostic significance of TMEM16A, PPFIA1, and FADD expression in invasive ductal carcinoma of the breast. World journal of surgical oncology. 12:137. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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