Name :
LONP1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
LONP1 Mouse Monoclonal antibody. Positive WB detected in human liver tissue, human heart tissue. Positive IHC detected in human liver tissue, human heart tissue, human lung cancer tissue. Positive IF detected in C6 cells. Observed molecular weight by Western-blot: 100kD
Tested applications :
ELISA, WB, IHC, IF
Species reactivity :
Human, Mouse, Rat; other species not tested.
Alternative names :
hLON antibody; LON antibody; lon peptidase 1 antibody; mitOChondrial antibody; Lon protease like protein antibody; LonHS antibody; LONP antibody; LONP1 antibody; PIM1 antibody; PRSS15 antibody; Serine protease 15 antibody
Immunogen :
Isotype :
Mouse IgG1
Preparation :
This antibody was obtained by immunization of LONP1 recombinant protein (Accession Number: NM_004793). Purification method: Protein G purified.
Clonality :
Monoclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200IF: 1:10-1:100
Background :
LONP1(Lon protease homolog, mitochondrial) is also named as LONP, LONHS, HLON, LON, PRSS15, PIM1, MGC1498 and belongs to the peptidase S16 family. It seems to play a major role in the elimination of oxidatively modified proteins in the mitochondrial matrix(PMID:18021745). LONP1, also a nuclearly encoded and mitochondrially located stress-responsive protease, is involved in heme-mediated ALAS-1 turnover(PMID:21659532). It recognizes specific surface determinants or folds, initiates proteolysis at solvent-accessible sites, and generates unfolded polypeptides that are then processively degraded(PMID:15870080).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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