Name :
LRDD antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
LRDD Rabbit Polyclonal antibody. Positive IHC detected in human pancreas tissue, human liver tissue. Positive IF detected in Hela cells. Positive IP detected in L02 cells. Positive WB detected in L02 cells, HEK-293 cells. Observed molecular weight by Western-blot: 55 kDa
Tested applications :
ELISA, IF, IP, WB, IHC
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
DKFZp434D229 antibody; LRDD antibody; PIDD antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of LRDD recombinant protein (Accession Number: NM_145887). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:1000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:10-1:100
Background :
P53-induced protein with a death domain (PIDD/LRDD) is a component of the PIDDosome. PIDD contains 910 residues with 7 leucine rich repeats (LRRs), 2 ZU-5 domains and a C-terminal death domain (DD). PIDD can be cleaved into shorter fragments generating a PIDD-N fragment of 48 kD (residues 1-446), a PIDD-C fragment of 51 kD (residues 447-910) and a PIDD-CC fragment of 37 kD (residues 589-910). Auto-cleavage of PIDD determines the downstream signaling events. The PIDD-C fragment mediates activation of NFκB via the recruitment of RIP1 and NEMO, while PIDD-CC causes caspase-2 activation, which leads to apoptosis.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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