Name :
LRP2-Specific antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
LRP2-Specific Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue. Positive FC detected in HEK-293 cells. Positive WB detected in HEK-293 cells, human brain tissue, human placenta tissue. Observed molecular weight by Western-blot: 280 kDa
Tested applications :
ELISA, WB, IHC, FC
Species reactivity :
Human; other species not tested.
Alternative names :
DBS antibody; Glycoprotein 330 antibody; gp330 antibody; LRP 2 antibody; LRP2 antibody; Megalin antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Peptide (Accession Number: NM_004525). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:1000IHC: 1:20-1:200
Background :
LRP2, also named as gp330 and Megalin, belongs to the LDLR family. It acts together with cubilin to mediate HDL endocytosis. LRP2 may participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release. Defects in LRP2 are the cause of Donnai-Barrow syndrome (DBS). The antibody is specific to LRP2.
References :
Sun C, Velazquez MA, Marfy-Smith S. Mouse early extra-embryonic lineages activate compensatory endocytosis in response to poor maternal nutrition. Development (Cambridge, England). 141(5):1140-50. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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