Name :
LRP5 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
LRP5 Rabbit Polyclonal antibody. Positive IHC detected in human liver cancer tissue, human hepat℃irrhosis tissue. Positive IF detected in HeLa cells. Positive WB detected in HeLa cells. Observed molecular weight by Western-blot: 200 kDa
Tested applications :
ELISA, WB, IHC, IF
Species reactivity :
Human; other species not tested.
Alternative names :
BMND1 antibody; EVR1 antibody; EVR4 antibody; HBM antibody; LR3 antibody; LRP 5 antibody; LRP5 antibody; LRP7 antibody; OPPG antibody; OPS antibody; OPTA1 antibody; VBCH2 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of LRP5 recombinant protein (Accession Number: NM_002335). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200IF: 1:50-1:500
Background :
Low-density lipoprotein receptor-related protein 5 (LRP5) is a single-pass type I membrane protein with EGF-like and LDLR domains in the extracellular domain. LRP5 and LRP6 act as coreceptors with Frizzled for Wnt. The complex of Wnt-Fzd-LRP5-LRP6 triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. LRP5 plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in LRP5 gene.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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