Name :
LRSAM1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
LRSAM1 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells, HepG2 cells, mouse liver tissue. Positive IHC detected in human skeletal muscle tissue. Positive IF detected in A431 cells. Observed molecular weight by Western-blot: 84 kDa
Tested applications :
ELISA, WB, IHC, IF
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
FLJ31641 antibody; hTAL antibody; LRSAM1 antibody; RIFLE antibody; TAL antibody; Tsg101 assOCiated ligase antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of LRSAM1 recombinant protein (Accession Number: NM_138361). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200IF: 1:10-1:100
Background :
LRSAM1 also named as hTAL, RIFLE orTsg101 associated ligase is a 723 amino acid protein, which contains 6 LRR repeats, 1 Ring-type zinc finger and 1 SAM domain. LRSAM1 is localizes in cytoplasm and highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue. As a E3 ubiquitin protein ligase, LRSAM1 mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic and exocytic cargos, LRSAM1 gene mutation has an association with Charcot Maire Tooth disease 2P.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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