Name :
LSM1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
LSM1 Rabbit Polyclonal antibody. Positive IHC detected in human prostate cancer tissue. Positive IP detected in HeLa cells. Positive WB detected in HeLa cells, mouse kidney tissue. Observed molecular weight by Western-blot: 18-20 kDa
Tested applications :
ELISA, IHC, WB, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
Cancer assOCiated Sm like antibody; CASM antibody; LSM1 antibody; Small nuclear ribonuclear CaSm antibody; YJL124C antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of LSM1 recombinant protein (Accession Number: NM_014462). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:1000IHC: 1:20-1:200
Background :
Lsm1 is a component of the Lsm1-7 complex involved in cytoplasmic mRNA degradation. Lsm1 is a key subunit that determines the RNA-binding properties of this complex. The normal RNA-binding activity of this complex is crucial for mRNA decay and 3′-end protection in vivo and requires the intact Sm-domain of Lsm1. LSM1 localizes to cytoplasmic processing bodies (P bodies) involved in mRNA storage, processing, regulation, and degradation and is required for P-body formation. LSM1 proteins facilitate the formation of U4/U6 RNA duplexes in vitro and may play a role in U4/U6 snRNP formation.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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