Name :
LSS antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
LSS Rabbit Polyclonal antibody. Positive IP detected in HepG2 cells. Positive WB detected in mouse testis tissue, HeLa cells, HepG2 cells, human brain tissue, mouse liver tissue, mouse pancreas tissue, PC-3 cells. Positive FC detected in HeLa cells. Positive IF detected in HepG2 cells. Positive IHC detected in human liver tissue, mouse testis tissue. Observed molecular weight by Western-blot: 70-75 kDa
Tested applications :
ELISA, WB, IP, IHC, IF, FC
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
FLJ25486 antibody; FLJ35015 antibody; FLJ39450 antibody; FLJ46393 antibody; hOSC antibody; Lanosterol synthase antibody; LSS antibody; OSC antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of LSS recombinant protein (Accession Number: NM_001001438). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:20-1:200
Background :
LSS, also named as OSC, is lanosterol synthase which catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. LSS gene has three isoforms with MW 74 kDa and 82-85 kDa. This antibody can recognize all these three isoforms.
References :
Fryer LG, Jones B, Duncan EJ. The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis. The Journal of biological chemistry. 289(7):4244-61. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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