Name :
LY96/MD2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
LY96/MD2 Rabbit Polyclonal antibody. Positive WB detected in U-937 cells. Positive IHC detected in human kidney tissue. Observed molecular weight by Western-blot: 20 kDa and 30 kDa and 35 kDa
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human; other species not tested.
Alternative names :
ESOP 1 antibody; ESOP1 antibody; Ly 96 antibody; LY96 antibody; lymphOCyte antigen 96 antibody; MD 2 antibody; MD2 antibody; Protein MD 2 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of LY96/MD2 recombinant protein (Accession Number: NM_015364). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200
Background :
LY96, also named as ESOP1 or MD 2, is a small secreted glycoprotein that can bind to both the hydrophobic portion of LPS and to the extracellular domain of TLR4. The interaction between MD-2 and LPS bridges the two TLR4 molecules and induces the dimerization of LPS-MD-2-TLR4, which forms the structural basis for biological functions of TLR4/MD-2 complex. Due to its essential role in mediating the interaction between LPS and TLR4, MD-2 has been extensively explored as a therapeutic target for treatment of inflammatory disorders.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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