Name :
MAD1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MAD1 Rabbit Polyclonal antibody. Positive IF detected in SH-SY5Y cells, A431 cells. Positive IHC detected in human brain tissue, human kidney tissue, human ovary tissue, human placenta tissue, human skin tissue, human spleen tissue, human testis tissue. Positive WB detected in A431 cells, HeLa cells, HepG2 cells, human brain tissue, Raji cells. Positive IP detected in HeLa cells. Observed molecular weight by Western-blot: 83 kDa
Tested applications :
ELISA, WB, IHC, IP, IF
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
hMAD1 antibody; HsMAD1 antibody; MAD1 antibody; MAD1 like protein 1 antibody; MAD1L1 antibody; PIG9 antibody; Tax binding protein 181 antibody; TP53I9 antibody; TXBP181 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MAD1 recombinant protein (Accession Number: NM_001304523). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:500-1:5000IHC: 1:20-1:200IF: 1:20-1:200
Background :
MAD1L1 is a component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. It recruits MAD2L1 to unattached kinetochores. Also it is required for anchoring MAD2L1 to the nuclear periphery. In addition, it binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding [PMID:10049595, 12837246].
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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