Name :
MAdCAM1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MAdCAM1 Rabbit Polyclonal antibody. Positive IHC detected in human tonsillitis tissue, human small intestine tissue.
Tested applications :
ELISA, IHC
Species reactivity :
Human; other species not tested.
Alternative names :
hMAdCAM 1 antibody; MACAM1 antibody; MAdCAM1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MAdCAM1 recombinant protein (Accession Number: BC142629). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: IHC: 1:20-1:200
Background :
Lymphocyte recirculation through different organs is thought to be regulated by adhesion molecules (“homing receptors”) recognizing tissue-specific vascular addressins on endothelium (PMID: 7511642). The mucosal vascular addressin, MAdCAM1, is an immunoglobulin superfamily adhesion receptor for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria (PMID: 7687523). MAdCAM1 can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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