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Name :
MAGEC2 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
MAGEC2 Rabbit Polyclonal antibody. Positive IHC detected in human testis tissue, human breast cancer tissue, human liver cancer tissue.

Tested applications :
ELISA, IHC

Species reactivity :
Human; other species not tested.

Alternative names :
Cancer/testis antigen 10 antibody; CT10 antibody; HCA587 antibody; MAGE C2 antigen antibody; MAGE E1 antigen antibody; MAGEC2 antibody; MAGEE1 antibody; melanoma antigen family C antibody; Melanoma assOCiated antigen C2 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of MAGEC2 recombinant protein (Accession Number: NM_016249). Purification method: Antigen affinity purified.

Clonality :
Polyclonal

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: IHC: 1:20-1:200

Background :
Melanoma antigen family C, 2(MAGEC2, synonyms: CT10, HCA587, MAGEE1, MGC13377) is related to members of the MAGEC gene family. MAGEC2 is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and other MAGEC genes are clustered on chromosome Xq26-q27.

References :
Sharma A, Bode B, Wenger RH. γ-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo. PloS one. 6(11):e28217. 2011. Weissferdt A, Rodriguez-Canales J, Liu H, Fujimoto J, Wistuba II, Moran CA. Primary mediastinal seminomas: a comprehensive immunohistochemical study with a focus on novel markers. Human pathology. 46(3):376-83. 2015.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel