Name :
MAGED1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MAGED1 Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells, Apoptosised HeLa cells, HeLa cells, human brain tissue. Positive FC detected in HeLa cells. Positive IHC detected in human gliomas tissue. Observed molecular weight by Western-blot: 66 kDa,92-95 kDa
Tested applications :
ELISA, WB, IHC, FC
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
DLXIN 1 antibody; MAGE D1 antigen antibody; MAGE tumor antigen CCF antibody; MAGED1 antibody; melanoma antigen family D antibody; Melanoma assOCiated antigen D1 antibody; NRAGE antibody; PP2250 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MAGED1 recombinant protein (Accession Number: NM_001005333). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200
Background :
MAGED1 (also known as NRAGE or Dlxin-1) is a member of the type II melanoma antigen (MAGE) family of protein. MAGED1 can interact with the nerve growth factor receptor p75NTR, antagonize the association of p75NTR with TrkA, inhibit cell cycle progression, and facilitate p75NTR-mediated apoptosis (PMID: 10985348). It has been reported that MAGED1 binds Dlx5 and regulates its transcriptional function. In vivo, MAGED1 binds not only Dlx5 but also Dlx7 and Msx2 and forms homomultimers (PMID: 11084035). MAGED1 knockout mice show depressive behavior and impairments of circadian rhythm (PMID: 20300063; 23314527).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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