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Name :
Acetyl-Histone H4-K5 mAb

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
Monoclonal antibody to Acetyl-Histone H4-K5

Tested applications :
WB, IHC, IF, IP

Species reactivity :
Human, Mouse, Rat

Alternative names :
HIST1H4B antibody; H4/I antibody; H4FI antibody; histone H4 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
Antigen: A specific peptide of human Acetyl-Histone H4-K5

Clonality :
Monoclonal

Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.

Applications :
WB 1:500 – 1:2000IHC 1:50 – 1:200IF 1:50 – 1:200IP 1:20 – 1:50

Background :
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel