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Name :
Anti-Cadherin-17/LI-cadherin antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
Rabbit polyclonal to Cadherin-17/LI-cadherin

Tested applications :
ELISA, WB, IHC-P, IP

Species reactivity :
Human CDH17 / Cadherin-17

Alternative names :
Cadherin-17 antibody; Cadherin-17 antibody; cdh17 antibody; CDH17 antibody; FLJ26931 antibody; CDH16 antibody; HPT1 antibody; HPT-1 antibody; HPT-1 antibody; HPT-1/LI antibody; LI-cadherin antibody; LI-cadherin antibody; MGC138218 antibody; MGC142024 antibody; RP23-54P14.2 antibody; HPT1 antibody; CDH16 antibody; HPT-1 antibody; HPT-1 antibody; HPT-1/LI antibody

Immunogen :
Human Cadherin-17/LI-cadherin (His Tag) recombinant protein

Isotype :
Rabbit IgG

Preparation :
Produced in rabbits immunized with purified, recombinant Human CDH17 / Cadherin-17 (rh CDH17 / Cadherin-17; Met 1-Met 787; Q12864-1). CDH17 / Cadherin-17 specific IgG was purified by Human CDH17 / Cadherin-17 affinity chromatography.

Clonality :
Polyclonal

Formulation :
0.2 μm filtered solution in PBS with 5% trehalose

Storage instructions :
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Applications :
WB: 1-5 μg/mLELISA: 0.1-0.2 μg/mLThis antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human CDH17. The detection limit for Human CDH17 is approximately 0.00975 ng/well.IHC-P: 0.1-2 μg/mLIP: 4-6 μg/mg of lysate

Background :
Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing of the encoding gene results in multiple transcript variants. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin-17 may thus contribute to the sorting of heterogeneous cell types and have a role in the morphological organization of liver and intestine. It’s also involved in intestinal peptide transport. Experiments have reported the association between Cadherin-17/LI-cadherin and gastric cancer. Cadherin-17/LI-cadherin expression was detected in 63/94 of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of Cadherin-17 tended to be associated with intestinal type carcinoma, and carcinomas with Cadherin-17 expression was significantly more frequent in advanced stage cases than in early stage. Cadherin-17 is also a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system.

References :
Liu LX, et al. (2009) Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma. Hepatology. 50(5): 1453-63. Ito R, et al. (2005) Clinicopathological significant and prognostic influence of cadherin-17 expression in gastric cancer. Virchows Arch. 447(4): 717-22. Horsfield J, et al. (2002) Cadherin-17 is required to maintain pronephric duct integrity during zebrafish development. Mech Dev. 115(1-2): 15-26.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel