Name :
MAGOH antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MAGOH Rabbit Polyclonal antibody. Positive IHC detected in human ovary tumor tissue. Positive WB detected in K-562 cells, HeLa cells, HL-60 cells, human brain tissue, Raji cells. Positive IP detected in K-562 cells. Observed molecular weight by Western-blot: 17 kDa
Tested applications :
ELISA, IHC, IP, WB
Species reactivity :
Human; other species not tested.
Alternative names :
MAGOH antibody; MAGOHA antibody; Protein mago nashi homolog antibody
Immunogen :
Human MAGOH Recombinant protein (GST tag)
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MAGOH recombinant protein (Accession Number: NM_002370). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000IHC: 1:20-1:200
Background :
MAGOH, belonging to the mago nashi family, is a component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). MAGOH regulates the transcriptional activation of STAT3 by interfering complex formation between STAT3 and a core EJC component Y14.
References :
Silver DL, Watkins-Chow DE, Schreck KC. The exon junction complex component Magoh controls brain size by regulating neural stem cell division. Nature neuroscience. 13(5):551-8. 2010. Zhao W, Zhou F, Zhou X. Mago, a vertebrate homolog of Drosophila Mago nashi protein, is a component of the chromatoid body in the cytoplasm of the postmeiotic spermatid. Journal of experimental zoology. Part B, Molecular and developmental evolution. 314(3):232-41. 2010. McMahon JJ, Shi L, Silver DL. Generation of a Magoh conditional allele in mice. Genesis (New York, N.Y. : 2000). 52(8):752-8. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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