Name :
MAML1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MAML1 Rabbit Polyclonal antibody. Positive WB detected in mouse heart tissue. Observed molecular weight by Western-blot: 108-120kd
Tested applications :
ELISA, WB
Species reactivity :
human, mouse, rat; other species not tested.
Alternative names :
MAML1 antibody; Mam1 antibody; KIAA0200 antibody; Mastermind like protein 1 antibody; Mam 1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Peptide (Accession Number: NM_014757). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000
Background :
MAML1, also named as KIAA0200 and Mam-1 , belongs to the mastermind family. It acts as a transcriptional coactivator for NOTCH proteins. MAML1 has been shown to amplify NOTCH-induced transcription of HES1. It enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. MAML1 binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. It plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. This antibody is specific to MAML1.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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