Name :
MAPKAPK2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MAPKAPK2 Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue, human breast cancer tissue. Positive IF detected in HeLa cells. Positive WB detected in HeLa cells, A549 cells, mouse colon tissue, mouse skeletal muscle tissue. Observed molecular weight by Western-blot: 47-50 kDa
Tested applications :
ELISA, WB, IHC, IF
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
MAPKAP kinase 2 antibody; MAPKAPK 2 antibody; MAPKAPK2 antibody; MK2 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MAPKAPK2 recombinant protein (Accession Number: NM_032960). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200IF: 1:50-1:500
Background :
MAPKAPK2(mitogen-activated protein kinase-activated protein kinase 2) is also named as MK2, MAPKAP-K2, MK-2 and belongs to the CAMK Ser/Thr protein kinase family. MAPKAPK2, one of several kinases directly phosphorylated and activated by p38 MAPK, plays a central role in the inflammatory response and is in the nucleus of unstimulated cells and moves rapidly to the cytoplasm after stimulation(PMID:12171911). It is also involved in many other cellular processes including stress responses, nuclear export, gene expression regulation and cell proliferation. Multiple residues of MAPKAPK2 are generally phosphorylated in vivo in response to stress, but only 4 residues(Thr25, Thr222, Ser272, and Thr334) are phosphorylated by p38 MAPK in vitro(PMID:22351694). It has 2 isoforms produced by alternative splicing and the range of the molecular weight is 42-60 kDa according to the references(PMID:10666409; 11328854;8995385).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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