Name :
Marcksl1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Marcksl1 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue. Observed molecular weight by Western-blot: 60kd
Tested applications :
ELISA, WB
Species reactivity :
human, mouse; other species not tested.
Alternative names :
Marcksl1 antibody; D4Bc1 antibody; AW215397 antibody; Mrp antibody; Macs2 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Recombinant Protein (Accession Number: NM_010807). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000
Background :
MacMARCKS is a member of MARCKS family of PKC substrate. It is widely used in the signal transduction studies as an indictor of PKC activation. The protein has a calculated molecular weight of 20 kDa and an apparent molecular weight of 42-45 kDa in different species on SDS PAGE. MacMARCKS functions in many aspects of cell physiology including integrin activation, cell spreading and phagocytosis. Its functions are though to associate with its ability in binding and regulating actin and microtubule cytoskeleton. Current evidence indicated that this protein also involved controls membrane fluidity and molecular mobility of membrane proteins
References :
Björkblom B, Padzik A, Mohammad H. c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells. Molecular and cellular biology. 32(17):3513-26. 2012. Ayyadurai S, Charania MA, Xiao B, Viennois E, Zhang Y, Merlin D. Colonic miRNA expression/secretion, regulated by intestinal epithelial PepT1, plays an important role in cell-to-cell communication during colitis. PloS one. 9(2):e87614. 2014. van den Bout I, Truong HH, Huveneers S, Kuikman I, Danen EH, Sonnenberg A. The regulation of MacMARCKS expression by integrin beta3. Experimental cell research. 313(6):1260-9. 2007. Wang J, Jarrett J, Huang CC, Satcher RL, Levenson AS. Identification of estrogen-responsive genes involved in breast cancer metastases to the bone. Clinical & experimental metastasis. 24(6):411-22. 2007.
Related websites: https://www.medchemexpress.com/antibodies.html
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