Name :
MASP1 Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to MASP1
Tested applications :
WB
Species reactivity :
Human, Mouse, Rat
Alternative names :
MASP1 antibody; 3MC1 antibody; CRARF antibody; CRARF1 antibody; MAP1 antibody; MASP antibody; MASP3 antibody; MAp44 antibody; PRSS5 antibody; RaRF antibody; mannan-binding lectin serine protease 1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human MASP1 (NP_001870.3).
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.
Applications :
WB 1:500 – 1:2000
Background :
Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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