Name :
Maspin antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Maspin Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, A431 cells, HeLa cells. Positive IHC detected in human lung cancer tissue, human breast cancer tissue. Observed molecular weight by Western-blot: 42 kDa
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
maspin antibody; Peptidase inhibitor 5 antibody; PI 5 antibody; PI5 antibody; Serpin B5 antibody; SERPINB5 antibody; SPB5 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Maspin recombinant protein (Accession Number: BC020713). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:50-1:500
Background :
SERPINB5, also named as PI-5, Maspin and Serpin B5, belongs to the serpin family and Ov-serpin subfamily. It is a tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, SERPINB5 exhibits no serine protease inhibitory activity.
References :
Baek JY, Yeo HY, Chang HJ. Serpin B5 is a CEA-interacting biomarker for colorectal cancer. International journal of cancer. 134(7):1595-604. 2014. Yang CF, Peng LX, Huang TJ. Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated apoptosis pathway. Cancer letters. 344(2):260-71. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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