Name :
Mast Cell Chymase antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Mast Cell Chymase Rabbit Polyclonal antibody. Positive WB detected in mouse heart tissue, human heart tissue, human placenta tissue, MCF7 cells. Positive IP detected in mouse heart tissue. Observed molecular weight by Western-blot: 27-30 kDa
Tested applications :
ELISA, WB, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
Alpha chymase antibody; chymase antibody; chymase 1 antibody; mast cell antibody; CMA1 antibody; CYH antibody; CYM antibody; Mast Cell Chymase antibody; Mast cell protease I antibody; Mcpt 5 antibody; Mcpt5 antibody; MCT1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Mast Cell Chymase recombinant protein (Accession Number: NM_001836). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:1000
Background :
Mast Cell Chymase, also named as CYH, CYM and CMA1, belongs to the peptidase S1 family and Granzyme subfamily. It is the major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. CMA1 maybe a target for cardiovascular disease therapies.
References :
Baumann A, Gönnenwein S, Bischoff SC. The circadian clock is functional in eosinophils and mast cells. Immunology. 140(4):465-74. 2013. Smith ET, Perry ET, Sears MB, Johnson DA. Expression of recombinant human mast cell chymase with Asn-linked glycans in glycoengineered Pichia pastoris. Protein expression and purification. 102:69-75. 2014. Shi H, Jiang H, Wang L. Overexpression of monocarboxylate anion transporter 1 and 4 in T24-induced cancer-associated fibroblasts regulates the progression of bladder cancer cells in a 3D microfluidic device. Cell cycle (Georgetown, Tex.). 14(19):3058-65. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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