Name :
MBD3 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MBD3 Rabbit Polyclonal antibody. Positive IP detected in mouse testis tissue. Positive WB detected in Y79 cells, COLO 320 cells, HeLa cells, Jurkat cells, MCF7 cells, mouse testis tissue. Positive IHC detected in human endometrial cancer tissue. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 33kd
Tested applications :
ELISA, WB, IHC, IF, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
MBD3 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MBD3 recombinant protein (Accession Number: NM_001281454). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:20-1:200
Background :
MBD3 does not bind DNA by itself. It recruits histone deacetylases and DNA methyltransferases. MBD3 acts as transcriptional repressor and plays a role in gene silencing.(PMID:9774669) .
References :
Ma P, Pan H, Montgomery RL, Olson EN, Schultz RM. Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development. Proceedings of the National Academy of Sciences of the United States of America. 109(8):E481-9. 2012.
Related websites: https://www.medchemexpress.com/antibodies.html
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