Name :
Anti-CALML5 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Rabbit polyclonal to CALML5
Tested applications :
ELISA, IHC-P
Species reactivity :
Human CALML5
Alternative names :
CALML5 antibody; CLSP antibody
Immunogen :
Human CALML5 (His & GST Tag) recombinant protein
Isotype :
Rabbit IgG
Preparation :
Produced in rabbits immunized with purified, recombinant Human CALML5 (rh CALML5; AAH39172.1; Met 1-Glu 146). CALML5 specific IgG was purified by Human CALML5 affinity chromatography.
Clonality :
Polyclonal
Formulation :
0.2 μm filtered solution in PBS with 5% trehalose
Storage instructions :
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Applications :
ELISA: 0.1-0.2 μg/mLThis antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human CALML5. The detection limit for Human CALML5 is approximately 0.00245 ng/well.IHC-P: 0.1-2 μg/mL
Background :
Calmodulin-like protein 5, also known as Calmodulin-like skin protein, CALML5 and CLSP, is a protein which contains four EF-hand domains. CALML5 / CLSP is particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation.The expression is very low in lung. CALML5 / CLSP binds calcium. It may be involved in terminal differentiation of keratinocytes. Coxsackievirus and adenovirus receptor (CAR) is a member of the immunoglobulin (Ig) superfamily and a component of epithelial tight junction. CAR functions as a primary receptor for coxsackievirus B and adenovirus (Ad) infection. CALML5 / CLSP is closely related to CAR. The structure and dynamics of human calmodulin-like skin protein CALML5 / CLSP have been characterized by NMR spectroscopy. The mobility of CALML5 / CLSP has been found to be different for the N-terminal and C-terminal domains. The N-terminal domain is characterized by four stable helices, which experience large fluctuations. This is shown to be due to mutations in the hydrophobic core. The overall N-terminal domain behavior is similar both in the full-length protein and in the isolated domain.
References :
Mehul B., et al., 2000, J. Biol. Chem. 275:12841-12847. Babini E., et al., 2006, Structure 14:1029-1038. Kawabata,K. et al., 2007, Gene Ther. 14 (16):1199-207.
Related websites: https://www.medchemexpress.com/antibodies.html
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