Name :
MCC antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MCC Rabbit Polyclonal antibody. Positive IHC detected in human prostate cancer tissue. Positive IF detected in PC-3 cells. Positive IP detected in PC-3 cells. Positive WB detected in human brain tissue, COLO 320 cells, mouse liver tissue, PC-3 cells. Observed molecular weight by Western-blot: 98 kDa; 113-118 kDa
Tested applications :
ELISA, IHC, IP, WB, IF
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
DKFZp762O1615 antibody; FLJ38893 antibody; FLJ46755 antibody; MCC antibody; MCC1 antibody; mutated in colorectal cancers antibody; Protein MCC antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MCC recombinant protein (Accession Number: NM_002387). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:10-1:100
Background :
MCC (mutated in colorectal cancers) gene been previously been identified by virtue of its mutation in human colorectal tumors. As a candidate for the putative colorectal tumor suppressor gene located at 5q21, MCC protein suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. In addition, MCC is involved in cell migration via binding with Srib and b-catenin,
References :
Rohrbeck A, Borlak J. Cancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1. PloS one. 4(10):e7315. 2009. Corbo C, Orrù S, Gemei M. Protein cross-talk in CD133+ colon cancer cells indicates activation of the Wnt pathway and upregulation of SRp20 that is potentially involved in tumorigenicity. Proteomics. 12(12):2045-59. 2012.
Related websites: https://www.medchemexpress.com/antibodies.html
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