Name :
MCM10 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MCM10 Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 97-105 kDa
Tested applications :
ELISA, WB, IF
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
CNA43 antibody; DNA43 antibody; HsMCM10 antibody; MCM10 antibody; PRO2249 antibody; Protein MCM10 homolog antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MCM10 recombinant protein (Accession Number: BC009108). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IF: 1:50-1:500
Background :
MCM10, also named as HsMCM10, belongs to the MCM10 family. It acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, it plays a role in preventing DNA damage during replication and is essential for the integrity of the RECQ4–MCM replicative helicase complex. It mediates RECQ4 association with MCM2-7 helicase complex during DNA replication.
References :
Xu X, Rochette PJ, Feyissa EA, Su TV, Liu Y. MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication. The EMBO journal. 28(19):3005-14. 2009. Mazurek A, Luo W, Krasnitz A, Hicks J, Powers RS, Stillman B. DDX5 regulates DNA replication and is required for cell proliferation in a subset of breast cancer cells. Cancer discovery. 2(9):812-25. 2012. Anantha RW, Alcivar AL, Ma J. Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination. PloS one. 8(4):e61368. 2013. Wang JT, Xu X, Alontaga AY, Chen Y, Liu Y. Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction. Cell reports. 7(3):848-58. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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