Name :
MCM3AP Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to MCM3AP
Tested applications :
WB
Species reactivity :
Human, Mouse, Rat
Alternative names :
MCM3AP antibody; GANP antibody; MAP80 antibody; SAC3 antibody; germinal-center associated nuclear protein antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 250-550 of human MCM3AP (NP_003897.2).
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.
Applications :
WB 1:500 – 1:2000
Background :
Isoform GANP: Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells (By similarity). Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.; Isoform MCM3AP: Acetyltransferase targeting MCM3. Inhibits initiation of DNA replication, but not elongation.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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