Name :
MCT4 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MCT4 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells. Positive FC detected in HepG2 cells. Positive IF detected in HepG2 cells. Positive IHC detected in human breast cancer tissue, human prostate cancer tissue, human skeletal muscle tissue. Observed molecular weight by Western-blot: 42-45 kDa
Tested applications :
ELISA, WB, IHC, IF, FC
Species reactivity :
Human; other species not tested.
Alternative names :
MCT 3 antibody; MCT 4 antibody; MCT3 antibody; MCT4 antibody; MonOCarboxylate transporter 3 antibody; MonOCarboxylate transporter 4 antibody; SLC16A3 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MCT4 recombinant protein (Accession Number: NM_001206951). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200IF: 1:20-1:200
Background :
The monocarboxylate transporter 4 (MCT4, also known as SLC16A3) is involved in the transportation of metabolically important monocarboxylates such as lactate, pyruvate, acetate and ketone bodies. It is widely expressed, particularly strongly in glycolytic tissues such as white skeletal muscle fibres, astrocytes, white blood cells, chondrocytes and some mammalian cell lines. MCT4 is also linked to tumor biology because it mediates lactate transport across membranes resulting in antiapoptotic effects.
References :
Shi H, Jiang H, Wang L. Overexpression of monocarboxylate anion transporter 1 and 4 in T24-induced cancer-associated fibroblasts regulates the progression of bladder cancer cells in a 3D microfluidic device. Cell cycle (Georgetown, Tex.). 14(19):3058-65. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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