Name :
MDC1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MDC1 Rabbit Polyclonal antibody. Positive IHC detected in human testis tissue, human appendix tissue, human breast cancer tissue. Positive IF detected in HEK-293 cells, HeLa cells.
Tested applications :
ELISA, IHC, IF
Species reactivity :
Human; other species not tested.
Alternative names :
DKFZp781A0122 antibody; KIAA0170 antibody; MDC1 antibody; NFBD1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MDC1 recombinant protein (Accession Number: BC152556). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: IHC: 1:20-1:200IF: 1:10-1:100
Background :
MDC1, also named as KIAA0170 or NFBD1, is a 2089 amino acid protein, which contains two BRCT domains and one FHA domain. MDC1 localizes in the nucleus and is highly expressed in testis. MDC1 is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. MDC1 may serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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