Name :
MDC1 Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to MDC1
Tested applications :
WB
Species reactivity :
Mouse
Alternative names :
MDC1 antibody; NFBD1 antibody; mediator of DNA damage checkpoint 1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MDC1 (NP_055456.2).
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.
Applications :
WB 1:500 – 1:2000
Background :
Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by ‘Ser-139’ phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5) Epigenetic Reader Domain
Phospho-PLK1(T210)Rabbit mAb In Vivo
Cytochrome P450 17A1 Antibody: Cytochrome P450 17A1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 57 kDa, targeting to Cytochrome P450 17A1. It can be used for WB,ICC,IF,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.
