Name :
ME2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
ME2 Rabbit Polyclonal antibody. Positive IP detected in HeLa cells. Positive WB detected in K-562 cells, HeLa cells, HL-60 cells, Jurkat cells. Observed molecular weight by Western-blot: 54 kDa, 65 kDa
Tested applications :
ELISA, WB, IP
Species reactivity :
Human; other species not tested.
Alternative names :
Malic enzyme 2 antibody; ME2 antibody; NAD ME antibody
Immunogen :
Human ME2 Recombinant protein (His tag)
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of ME2 recombinant protein (Accession Number: NM_001168335). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000
Background :
ME2(malic enzyme 2) is also named as NAD-ME and belongs to the malic enzymes family. ME1, ME2 are important for NADPH production, lipogenesis and glutamine metabolism, but ME2 has a more profound effect. ME2 is a genome-coded mitochondrial enzyme that converts malate to pyruvate and is involved in neuronal synthesis of the neurotransmitter γ-aminobutyric acid (GABA)(PMID:15532013). This protein has 2 isoforms produced by alternative splicing with the MW of 65 kDa and 54 kDa.
References :
Sun L, Song L, Wan Q. cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. Cell research. 25(4):429-44. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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