Name :
Anti-Calsyntenin-1 / CLSTN1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Rabbit polyclonal to Calsyntenin-1 / CLSTN1
Tested applications :
ELISA, IHC-P
Species reactivity :
Human Calsyntenin-1 / CLSTN1
Alternative names :
RP11-558F24.5 antibody; ALC-ALPHA antibody; CDHR12 antibody; CSTN1 antibody; PIK3CD antibody; XB31alpha antibody; alcalpha1 antibody; alcalpha2 antibody; KIAA0911 antibody; RP23-422H14.2 antibody; 1810034E21Rik antibody; Cst-1 antibody; Cstn1 antibody; Kiaa0911 antibody; CST-1 antibody; CSTN1 antibody; CDHR12 antibody; PIK3CD antibody; ALC-ALPHA antibody; XB31alpha antibody; alcalpha1 antibody; alcalpha2 antibody; Cst-1 antibody; Cstn1 antibody; 1810034E21Rik antibody
Immunogen :
Human Calsyntenin-1 / CLSTN1 (His Tag) recombinant protein
Isotype :
Rabbit IgG
Preparation :
Produced in rabbits immunized with purified, recombinant Human Calsyntenin-1 / CLSTN1 (rh Calsyntenin-1 / CLSTN1; NP_001009566.1; Met1-Thr859). Calsyntenin-1 / CLSTN1 specific IgG was purified by Human Calsyntenin-1 / CLSTN1 affinity chromatography.
Clonality :
Polyclonal
Formulation :
0.2 μm filtered solution in PBS with 5% trehalose
Storage instructions :
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Applications :
ELISA: 0.1-0.2 μg/mLThis antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human Calsyntenin-1 / CLSTN1. The detection limit for Human Calsyntenin-1 / CLSTN1 is IHC-P: 0.1-2 μg/ml
Background :
Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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