Name :
MEK2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MEK2 Rabbit Polyclonal antibody. Positive IP detected in HL-60 cells. Positive WB detected in HL-60 cells, human brain tissue, Jurkat cells, SH-SY5Y cells. Positive IF detected in SH-SY5Y cells. Observed molecular weight by Western-blot: 44-47 kDa
Tested applications :
ELISA, WB, IF, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
ERK activator kinase 2 antibody; FLJ26075 antibody; MAP kinase kinase 2 antibody; MAP2K2 antibody; MAPK/ERK kinase 2 antibody; MAPKK 2 antibody; MAPKK2 antibody; MEK 2 antibody; MEK2 antibody; MKK2 antibody; PRKMK2 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MEK2 recombinant protein (Accession Number: NM_030662). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:500-1:5000IF: 1:10-1:100
Background :
MEK2(MAPK/ERK kinase 2) is also named as MAP2K2, MKK2, PRKMK2 and Belongs to the MAP kinase kinase subfamily. MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). MEK1 and MEK2 are closely related, dual-specificity tyrosine/threonine protein kinases found in the Ras/Raf/MEK/ERK mitogen-activated protein kinase (MAPK) signaling pathway. 11049-1-AP can recognize both the MEK2 and MEK1.
References :
Wang Y, Luo H, Li Y, Chen T, Wu S, Yang L. hsa-miR-96 up-regulates MAP4K1 and IRS1 and may function as a promising diagnostic marker in human bladder urothelial carcinomas. Molecular medicine reports. 5(1):260-5. 2012. Li XL, Chen XQ, Zhang MN. SOX9 was involved in TKIs resistance in renal cell carcinoma via Raf/MEK/ERK signaling pathway. International journal of clinical and experimental pathology. 8(4):3871-81. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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