Name :
Melanophilin antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Melanophilin Mouse Monoclonal antibody. Positive IF detected in HepG2 cells. Positive IHC detected in human skin cancer tissue, human kidney tissue. Positive WB detected in PC-3 cells, HEK-293 cells. Observed molecular weight by Western-blot: 66kD,63kD
Tested applications :
ELISA, WB, IF, IHC
Species reactivity :
Human; other species not tested.
Alternative names :
Exophilin 3 antibody; melanophilin antibody; MLPH antibody; SLAC2 A antibody; SLAC2A antibody; Synaptotagmin like protein 2a antibody
Immunogen :
Isotype :
Mouse IgG1
Preparation :
This antibody was obtained by immunization of Melanophilin recombinant protein (Accession Number: NM_024101). Purification method: Protein G purified.
Clonality :
Monoclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200IF: 1:10-1:100
Background :
Melanophilin (MLPH) is a member of the exophilin subfamily of Rab effector proteins. MLPH is a modular protein, forming a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. It regulates retention of melanosomes at the peripheral actin cytoskeleton of melanocytes, a process essential for normal mammalian pigmentation. Defects in MLPH are a cause of Griscelli syndrome type 3 (GS3), which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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