Name :
Anti-CaM Kinase 4/CaMKIV antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Rabbit monoclonal to CaM Kinase 4/CaMKIV
Tested applications :
IHC-P
Species reactivity :
Mouse CaM Kinase 4 / CaMKIV
Alternative names :
A430110E23Rik antibody; caMK antibody; CaMK IV antibody; Camk4 antibody; CaMK-GR antibody; CaMKIV antibody; CaMKIV/Gr antibody; CAMK antibody; CaMKIV antibody; AI666733 antibody; CaMKIV/Gr antibody; D18Bwg0362e antibody; A430110E23Rik antibody; IV antibody; CaMKIV antibody; CaMK-GR antibody; AI666733 antibody; caMK IV antibody; CAMK4 antibody; D18Bwg0362e antibody; IV antibody; MGC36771 antibody
Immunogen :
Mouse CaM Kinase 4/CaMKIV (His & GST Tag) recombinant protein
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CaM Kinase 4 / CaMKIV (rM CaM Kinase 4 / CaMKIV; P08414; Met1-Tyr469).
Clonality :
Monoclonal
Formulation :
0.2 μm filtered solution in PBS
Storage instructions :
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Applications :
IHC-P: 1-10μg/mL
Background :
Ca2+/ calmodulin-dependent protein kinase 4 (CAMKⅣ) belongs to the serine/threonine protein kinase family, and to the Ca2+/calmodulin-dependent protein kinase subfamily which is widely recognized as an essential enzyme implicated in the phophoinositide amplification cascade. Ca2+/calmodulin dependent protein kinase (CAMK) can be activated by the introcellular increased Ca2+ and then apt to combine with the target protein. Ca2+/ calmodulin-dependent protein kinase 4 (CAMKⅣ) is a multifunctional CaM-dependent kinase protein with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. All of the isforms of this family, including myosin light chain kinase, phosphorylase kinase, CaMK1, CaMKⅢ and CaMKⅣ have EF-hand structure.
References :
Feliciano DM, et al. (2009) Repression of Ca2+/calmodulin-dependent protein kinase IV signaling accelerates retinoic acid-induced differentiation of human neuroblastoma cells. J Biol Chem. 284 (39): 26466-81. Zhao X, et al. (2001). The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking. J Biol Chem. 276 (37): 35042-8. Racioppi L, et al. (2008) Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller.
Related websites: https://www.medchemexpress.com/antibodies.html
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