Name :
MEN1 Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to MEN1
Tested applications :
WB, IHC
Species reactivity :
Human, Mouse, Rat
Alternative names :
MEN1 antibody; MEAI antibody; SCG2 antibody; menin antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: Recombinant protein of human MEN1
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.
Applications :
WB 1:500 – 1:1000IHC 1:50 – 1:100
Background :
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates ‘Lys-4’ of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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