Name :
MGEA5 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MGEA5 Mouse Monoclonal antibody. Positive IHC detected in human meningioma tissue, human brain tissue, human gliomas tissue. Positive IF detected in HepG2 cells, Hela cells. Positive WB detected in Human brain tissue, human liver tissue. Observed molecular weight by Western-blot: 75kD,130kD
Tested applications :
ELISA, WB, IF, IHC
Species reactivity :
Human; other species not tested.
Alternative names :
Beta N acetylhexosaminidase antibody; Bifunctional protein NCOAT antibody; FLJ11229 antibody; FLJ23355 antibody; HAT antibody; HEXC antibody; Hexosaminidase C antibody; KIAA0679 antibody; MEA5 antibody; Meningioma expressed antigen 5 antibody; MGEA5 antibody; N acetyl beta glucosaminidase antibody; NCOAT antibody; O GlcNAcase antibody; OGA antibody
Immunogen :
Human MGEA5 Recombinant protein (His tag)
Isotype :
Mouse IgG1
Preparation :
This antibody was obtained by immunization of MGEA5 recombinant protein (Accession Number: BC039583). Purification method: Protein G purified.
Clonality :
Monoclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200IF: 1:20-1:200
Background :
Human meningioma-expressed antigen 5 (MGEA5) has two putative domains including protein O-GlcNAcase domain and histone acetyltransferase domain, therefore it is often called bifunctional protein NCOAT. Three isoforms of MEGE5 are produced by alternative splicing. MGEA5 was found to be regulated to reduce the state of glycosylation of transcitpional activators while increasing the acetylation of histones to allow for the concerted activation of eukaryotic gene transcription, for instance, acetylation of Lys8 of histone H4 and Lys 14 of histone H3 are resulted from acetyltransferase activity. In addition, single nucleotide polymorphism in MGE5A is associated with type 2 diabetes in Mexican Americans. Two bands at 130kDa and 75 kDa could be detected using the present mouse monopolyclonal antibody 66033-1-Ig, which is consistent with results in a related reference (PubMed:11341771).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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