Name :
MIB1 Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to MIB1
Tested applications :
WB, IHC
Species reactivity :
Human, Mouse, Rat
Alternative names :
MIB1 antibody; DIP-1 antibody; DIP1 antibody; LVNC7 antibody; MIB antibody; ZZANK2 antibody; ZZZ6 antibody; E3 ubiquitin-protein ligase MIB1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 560-860 of human MIB1 (NP_065825.1).
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.
Applications :
WB 1:500 – 1:2000IHC 1:100 – 1:200
Background :
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates ‘Lys-63’-linked polyubiquitination of TBK1, which probably participates in kinase activation.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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