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Name :
MIP-3-beta antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
MIP-3-beta Rabbit Polyclonal antibody. Positive IHC detected in human lymphoma tissue. Positive IF detected in A549 cells. Positive WB detected in A549 cells, HepG2 cells. Observed molecular weight by Western-blot: 12 kDa

Tested applications :
ELISA, WB, IHC, IF

Species reactivity :
Human; other species not tested.

Alternative names :
Beta chemokine exodus 3 antibody; C C motif chemokine 19 antibody; CCL19 antibody; CK beta 11 antibody; CKb11 antibody; EBI1 ligand chemokine antibody; ELC antibody; MIP 3 beta antibody; MIP 3b antibody; MIP3B antibody; MIP-3-beta antibody; SCYA19 antibody; Small inducible cytokine A19 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of MIP-3-beta recombinant protein (Accession Number: NM_006274). Purification method: Antigen affinity purified.

Clonality :
Polyclonal

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200IF: 1:20-1:200

Background :
CCL19, also known as MIP-3β, is one of several CC cytokine genes clustered on the p-arm of chromosome 9. CCL19 may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.

References :
Perros F, Dorfmüller P, Montani D. Pulmonary lymphoid neogenesis in idiopathic pulmonary arterial hypertension. American journal of respiratory and critical care medicine. 185(3):311-21. 2012. Mathes AL, Christmann RB, Stifano G. Global chemokine expression in systemic sclerosis (SSc): CCL19 expression correlates with vascular inflammation in SSc skin. Annals of the rheumatic diseases. 73(10):1864-72. 2014.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel