Name :
MKS3 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MKS3 Rabbit Polyclonal antibody. Positive IF detected in hTERT-RPE1 cells. Positive IHC detected in human kidney tissue, human hepat℃irrhosis tissue.
Tested applications :
ELISA, IF, IHC
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
JBTS6 antibody; Meckel syndrome type 3 protein antibody; MECKELIN antibody; MKS3 antibody; TMEM67 antibody; TNEM67 antibody; transmembrane protein 67 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MKS3 recombinant protein (Accession Number: BC032835). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: IHC: 1:20-1:200IF: 1:20-1:200
Background :
TMEM67 represents transmembrane protein 67
References :
Garcia-Gonzalo FR, Corbit KC, Sirerol-Piquer MS. A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition. Nature genetics. 43(8):776-84. 2011. Goetz SC, Liem KF, Anderson KV. The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis. Cell. 151(4):847-58. 2012. Wang WJ, Tay HG, Soni R. CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base. Nature cell biology. 15(6):591-601. 2013. Yang Y, Ran J, Liu M. CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6. Cell research. 24(11):1342-53. 2014. Barbelanne M, Hossain D, Chan DP, Peränen J, Tsang WY. Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery. Human molecular genetics. 24(8):2185-200. 2015. Roberson EC, Dowdle WE, Ozanturk A. TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone. The Journal of cell biology. 209(1):129-42. 2015. Ran J, Yang Y, Li D, Liu M, Zhou J. Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly. Scientific reports. 5:12917. 2015. Lu Q, Insinna C, Ott C. Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation. Nature cell biology. 17(4):531. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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